Assessment 3
Question 2
Which of the following onset intervals of severe adverse events following immunization is probably not due to the given vaccine?
Select one or more:
| A. Vaccine-associated paralytic poliomyelitis (VAPP) occurring 4 – 30 days after vaccination. | |
| B. Febrile seizures occurring 6 – 12 days following measles vaccination. | |
| C. Thrombocytopenia occurring 15 – 35 days after vaccination. | |
| D. Anaphylaxis occuring 2 – 3 days after vaccination. | |
| E. Prolonged crying for 0 – 24 hours after vaccination. |
Answer D is incorrect.
Anaphylaxis has an onset interval of up to 1 hour following vaccination.
Severe vaccine reactions, onset interval, and rates associated with selected childhood vaccines
| Vaccine | Reaction* | Onset interval26 | Frequency per doses given |
|---|---|---|---|
| BCG28 | Fatal dissemination of BCG infection | 1 – 12 months | 0.19 – 1.56/1,000,000 |
| OPV29 | Vaccine associated paralytic poliomyelitis (VAPP)** | 4 – 30 days | 2 – 4/1,000,000 |
| DTwP30 | Prolonged crying and seizures*** | 0 – 24 hours | < 1/100 |
| HHE | 0 – 24 hours | < 1/1,000 – 2/1,000 | |
| Measles31 | Febrile seizures | 6 – 12 days | 1/3,000 |
| Thrombocytopenia | 15 – 35 days | 1/30,000 | |
| Anaphylaxis | 1 hour | 1/100,000 |
* Reactions (except anaphylaxis) do not occur if already immune (90% of those receiving a second dose); children >6 years unlikely to have febrile seizures.
** VAPP risk higher for first dose (1 in 750 000 compared with 1 in 5.1 million for subsequent doses), and for adults and immunocompromised clients.
*** Seizures are mostly febrile. The risk of having a seizure depends on the persons age. The risk is much lower in infants <4 months of age.